Editing Amygdala (section)

===Alcoholism===
The amygdala appears to play a role in [[binge drinking]], being damaged by repeated episodes of intoxication and withdrawal.<ref>{{cite journal | vauthors = Stephens DN, Duka T | title = Review. Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortex | journal = Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences | volume = 363 | issue = 1507 | pages = 3169–79 | date = October 2008 | pmid = 18640918 | pmc = 2607328 | doi = 10.1098/rstb.2008.0097 }}</ref><ref name=":0">{{cite journal|vauthors=Marinkovic K, Oscar-Berman M, Urban T, O'Reilly CE, Howard JA, Sawyer K, Harris GJ|date=November 2009|title=Alcoholism and dampened temporal limbic activation to emotional faces|journal=Alcoholism: Clinical and Experimental Research|volume=33|issue=11|pages=1880–92|doi=10.1111/j.1530-0277.2009.01026.x|pmc=3543694|pmid=19673745}}</ref> [[PRKCE|Protein kinase C-epsilon]] in the amygdala is important for regulating behavioral responses to [[morphine]] and [[ethanol]] and controlling anxiety-like behavior. The protein is involved in controlling the function of other proteins and plays a role in the development of the ability to consume a large amount of ethanol.<ref>{{cite journal|vauthors=Newton PM, Ron D|date=June 2007|title=Protein kinase C and alcohol addiction|journal=Pharmacological Research|volume=55|issue=6|pages=570–7|doi=10.1016/j.phrs.2007.04.008|pmid=17566760}}</ref><ref>{{cite journal|vauthors=Lesscher HM, Wallace MJ, Zeng L, Wang V, Deitchman JK, McMahon T, Messing RO, Newton PM|date=July 2009|title=Amygdala protein kinase C epsilon controls alcohol consumption|journal=Genes, Brain and Behavior|volume=8|issue=5|pages=493–9|doi=10.1111/j.1601-183X.2009.00485.x|pmc=2714877|pmid=19243450}}</ref> The duration of chronic alcohol consumption and abstinence may affect dynamic brain network adaptations.<ref name=":0" /> When excessive drinking occurs, the amygdala is affected through behavioral changes and reduces the [[Neuroplasticity|brain's plasticity]]. Often, when binge drinking or alcoholism occurs, the amygdala is affected and leads to behavior damage. These behavioral damages can be lack of control, inability to conduct oneself in a mature manner, irritability and aggressive behavior, anxiety, depression, personality disorders, excessive drug intake, bipolar disorder, confusion, higher tolerance levels, and inappropriate sexual behaviors with others and self.<ref>{{Cite journal|last1=Stephens|first1=David N|last2=Duka|first2=Theodora|date=2008-10-12|title=Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortex|journal=Philosophical Transactions of the Royal Society B: Biological Sciences|volume=363|issue=1507|pages=3169–3179|doi=10.1098/rstb.2008.0097|issn=0962-8436|pmc=2607328|pmid=18640918}}</ref>