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==Precautions== <sup>227</sup>Ac is highly radioactive and experiments with it are carried out in a specially designed laboratory equipped with a tight [[glove box]]. When actinium trichloride is administered intravenously to rats, about 33% of actinium is deposited into the bones and 50% into the liver. Its toxicity is comparable to, but slightly lower, than that of americium and plutonium.<ref>{{cite journal |doi = 10.2172/4406766 |title = Toxicology of Actinium Equilibrium Mixture |first2 = J. |last1 = Langham |last2 = Storer |first1 = W. |date = 1952 | journal = Los Alamos Scientific Lab.: Technical Report|url=https://digital.library.unt.edu/ark:/67531/metadc1024446/ }}</ref> For trace quantities, fume hoods with good aeration suffice; for gram amounts, [[hot cell]]s with shielding from the intense gamma radiation emitted by <sup>227</sup>Ac are necessary.<ref>{{Ullmann | first1=Cornelius |last1=Keller |first2=Walter |last2=Wolf |first3=Jashovam |last3=Shani | title = Radionuclides, 2. Radioactive Elements and Artificial Radionuclides | doi = 10.1002/14356007.o22_o15}}</ref>
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