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==Signs and symptoms== Yellow fever begins after an incubation period of three to six days.<ref name="urlFact Sheet | CDC Yellow Fever">{{cite web |url=https://www.cdc.gov/yellowfever/symptoms/index.html |title=CDC: Yellow fever—Symptoms and treatment |access-date=2010-11-10 |url-status=live |archive-url=https://web.archive.org/web/20120321164313/http://www.cdc.gov/yellowfever/symptoms/index.html |archive-date=2012-03-21 }}</ref> Most cases cause only mild infection with fever, headache, chills, back pain, fatigue, loss of appetite, muscle pain, nausea, and vomiting.<ref name="urlWHO | Yellow fever">{{cite web |url=https://www.who.int/mediacentre/factsheets/fs100/en/ |title=Yellow fever |publisher=WHO |access-date=2009-08-13 |url-status=live |archive-url=https://web.archive.org/web/20090817074958/http://www.who.int/mediacentre/factsheets/fs100/en/ |archive-date=2009-08-17 }}</ref> In these cases, the infection lasts only three to six days.<ref>{{Cite web|title=Yellow fever|url=https://www.who.int/news-room/fact-sheets/detail/yellow-fever|access-date=2021-07-11|website=World Health Organization|language=en}}</ref> But in 15% of cases, people enter a second, toxic phase of the disease characterized by recurring fever, this time accompanied by [[jaundice]] due to [[hepatitis|liver damage]], as well as [[abdominal pain]].<ref>{{cite book |title=Control of Communicable Diseases Manual |publisher=Amer Public Health Assn |isbn=978-0-87553-018-5 |edition=20th |year=2015}}</ref> Bleeding in the mouth, nose, eyes, and the [[Human gastrointestinal tract|gastrointestinal tract]] cause [[hematemesis|vomit containing blood]], hence one of the names in Spanish for yellow fever, {{lang|es|vómito negro}} ("black vomit").<ref name="pmid14582304">{{cite journal | vauthors = Chastel C | title = [Centenary of the discovery of yellow fever virus and its transmission by a mosquito (Cuba 1900-1901)] | language = fr | journal = Bulletin de la Socitété de Pathologie Exotique | volume = 96 | issue = 3 | pages = 250–256 | date = August 2003 | pmid = 14582304 }}</ref> There may also be kidney failure, hiccups, and delirium.<ref>Dr. [[Irwin Sherman]], ''Twelve Diseases that Changed Our World''. p. 144. ASM Press. 2007. {{ISBN|978-1-55581-466-3}}. {{OCLC|141178241}}.</ref><ref>Franklin, Jon; Sutherland, John. ''[[Guinea Pig]] Doctors: The Drama of Medical Research Through Self-Experimentation'', New York: William Morrow & Co (March 1984) {{ISBN|0-688-02666-4}}</ref> Among those who develop jaundice, the fatality rate is 20 to 50%, while the overall [[case fatality rate|fatality rate]] is about 3 to 7.5%.<ref name="pmid18061688">{{cite journal | vauthors = Monath TP | title = Treatment of yellow fever | journal = Antiviral Research | volume = 78 | issue = 1 | pages = 116–124 | date = April 2008 | pmid = 18061688 | doi = 10.1016/j.antiviral.2007.10.009 }}</ref> Severe cases may have a mortality rate greater than 50%.<ref name=Tomori2004>{{cite journal | vauthors = Tomori O | title = Yellow fever: the recurring plague | journal = Critical Reviews in Clinical Laboratory Sciences | volume = 41 | issue = 4 | pages = 391–427 | year = 2004 | pmid = 15487593 | doi = 10.1080/10408360490497474 }}</ref> Surviving the infection provides lifelong [[Immunity (medical)|immunity]],<ref>{{cite book | vauthors = Modrow S, Falke D, Truyen U |title=Molekulare Virologie – Eine Einführung für Biologen und Mediziner |publisher=Spektrum Akademischer Verlag |year=2002 |isbn=978-3-8274-1086-3 |page=182 |edition=2nd }}</ref> and normally results in no permanent organ damage.<ref name="pmid16647971">{{cite book | vauthors = Rogers DJ, Wilson AJ, Hay SI, Graham AJ | title = Global Mapping of Infectious Diseases: Methods, Examples and Emerging Applications | chapter = The global distribution of yellow fever and dengue | volume = 62 | pages = 181–220 | year = 2006 | pmid = 16647971 | pmc = 3164798 | doi = 10.1016/S0065-308X(05)62006-4 | isbn = 978-0-12-031762-2 | series = Advances in Parasitology }}</ref><ref>{{Cite web |date=2020-02-26 |title=Symptoms, Diagnosis, & Treatment |url=https://www.cdc.gov/yellowfever/symptoms/index.html |access-date=2022-04-30 |website=www.cdc.gov |language=en-us}}</ref> === Complication === Yellow fever can lead to death for 20% to 50% of those who develop severe disease. Jaundice, fatigue, heart rhythm problems, seizures and internal bleeding may also appear as complications of yellow fever during recovery time.<ref name="mayoclinic"/><ref>{{Cite web |title=Yellow Fever: Symptoms, Complications, and Treatment |url=https://www.practo.com/health-wiki/yellow-fever-symptoms-complications-and-treatment/67/article |access-date=2022-03-31 |website=Practo}}</ref>
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