Editing Wild type (section)

==Medical applications==
The genetic sequence for wild-type versus "mutant" phenotypes and how these genes interact in expression is the subject of much research.  Better understanding of these processes is hoped to bring about methods for preventing and curing diseases that are currently incurable such as infection with the herpes virus.<ref>{{cite journal|last1=Batista, Franco, Vicentini, Spilki, Silva, Adania, Roehe|title=Neutralizing Antibodies against Feline Herpesvirus Type 1 in Captive Wild Felids of Brazil|journal=Journal of Zoo and Wildlife Medicine|doi=10.1638/04-060.1|pmid=17312763|volume=36|issue=3|pages=447–450|year=2005|s2cid=42233414}}</ref> One example of such promising research in these fields was the study done examining the link between wild-type mutations and certain types of lung cancer.<ref>{{cite journal|last1=Zhao, Zhang, Yan, Yang, Wu|title=Efficacy of epidermal growth factor receptor inhibitors versus chemotherapy as second-line treatment in advanced non-small-cell lung cancer with wild-type EGFR: A meta-analysis of randomized controlled clinical trials|journal=Lung Cancer|date=July 2014|volume=85|issue=1|pages=66–73|doi=10.1016/j.lungcan.2014.03.026|pmid=24780111}}</ref>  Research is also being done dealing with the manipulation of certain wild-type traits in viruses to develop new vaccines.<ref>{{cite web|last1=Sanchez|first1=Anthony|title=Analysis of Filovirus Entry into Vero E6 Cells, Using Inhibitors of Endocytosis, Endosomal Acidification, Structural Integrity, and Cathepsin (B and L) Activity|url=http://jid.oxfordjournals.org/content/196/Supplement_2/S251.abstract|website=oxfordjournals.org|publisher=The Journal of Infectious Diseases|access-date=2014-11-16}}</ref> This research may lead to new ways to combat deadly viruses such as the [[Ebola virus disease|Ebola virus]]<ref>{{cite journal|last1=Sullivan|first1=Nancy|last2=Yang|first2=Zhi-Yong|last3=Nabel|first3=Gary|title=Ebola Virus Pathogenesis: Implications for Vaccines and Therapies|url= |journal=Journal of Virology|volume=77|issue=18|pages=9733–9737|doi=10.1128/JVI.77.18.9733-9737.2003|pmid=12941881|year=2003|pmc=224575}}</ref> and [[HIV]].<ref>{{cite journal|last1=Quan|first1=Yudong|last2=Xu|first2=Hongtao|last3=Kramer|first3=Vintor|last4=Han|first4=Yingshan|last5=Sloan|first5=Richard|last6=Wainberg|first6=Mark|title=Identification of an env-defective HIV-1 mutant capable of spontaneous reversion to a wild-type phenotype in certain T-cell lines|journal=Virology Journal|volume=11|pages=177|doi=10.1186/1743-422X-11-177|pmid=25287969|pmc=4283149|year=2014 |doi-access=free }}</ref> Research using wild-type mutations is also being done to establish how viruses transition between species to identify harmful viruses with the potential to infect humans.<ref>{{cite journal|last1=Bieringer|first1=Maria|last2=Han|first2=Jung|last3=Kendl|first3=Sabine|last4=Khosravi|first4=Mojtaba|last5=Plattet|first5=Philippe|last6=Schneider-Schaulies|first6=Jürgen|title=Experimental Adaptation of Wild-Type Canine Distemper Virus (CDV) to the Human Entry Receptor CD150|journal=PLOS ONE|volume=8|issue=3|pages=e57488|doi=10.1371/journal.pone.0057488|pmid=23554862|pmc=3595274|year=2013|bibcode=2013PLoSO...857488B|doi-access=free}}</ref>