Editing Trimethoprim (section)

==Medical uses==
It is primarily used in the treatment of [[urinary tract infections]], although it may be used against any susceptible [[Aerobic organism|aerobic bacterial species]].<ref name="AMH">{{cite book | veditors = Rossi S | isbn = 978-0-9805790-9-3 | title = Australian Medicines Handbook | place = Adelaide | publisher = The Australian Medicines Handbook Unit Trust | year = 2013 | edition = 2013 }}</ref> It may also be used to treat and prevent ''[[Pneumocystis jirovecii]]'' pneumonia.<ref name = AMH/> It is generally not recommended for the treatment of [[Anaerobic organism|anaerobic infections]] such as [[Clostridioides difficile infection|''Clostridioides difficile'' colitis]] (the leading cause of antibiotic-induced diarrhea).<ref name = AMH/> Trimethoprim has been used in trials to treat [[toxoplasmic chorioretinitis|retinitis]].<ref name="Pradhan">{{cite journal | vauthors = Pradhan E, Bhandari S, Gilbert RE, Stanford M | title = Antibiotics versus no treatment for toxoplasma retinochoroiditis | journal = The Cochrane Database of Systematic Reviews | volume = 2016 | issue = 5 | pages = CD002218 | date = May 2016 | pmid = 27198629 | pmc = 7100541 | doi = 10.1002/14651858.CD002218.pub2 }}</ref>

Resistance to trimethoprim is increasing, but it is still a first-line antibiotic in many countries.<ref>{{cite web |url=https://www.nice.org.uk/advice/ktt10/chapter/evidence-context |title=Three-day courses of antibiotics for uncomplicated urinary tract infection &#124; Guidance and guidelines &#124; NICE |date=15 January 2015 |access-date=30 December 2015 |url-status=live |archive-url=https://web.archive.org/web/20151208004951/http://www.nice.org.uk/advice/ktt10/chapter/Evidence-context |archive-date=8 December 2015 }}</ref>

===Spectrum of susceptibility===
Cultures and susceptibility tests should be done to make sure bacteria are treated by trimethoprim.<ref name="dailymed.nlm.nih.gov">{{Cite web| work  = DailyMed | title = TRIMETHOPRIM- trimethoprim tablet|url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4e9183f-d0eb-4ba7-9204-760b1fd62010| publisher = U.S. National Library of Medicine |access-date = 4 November 2015|url-status = live|archive-url = https://web.archive.org/web/20150930162821/http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4e9183f-d0eb-4ba7-9204-760b1fd62010|archive-date = 30 September 2015}}</ref><ref>{{Cite web| work = DailyMed | title = PRIMSOL- trimethoprim hydrochloride solution|url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a06ea7d8-a884-4b62-a87f-c36d824f2aa4| publisher = U.S. National Library of Medicine  |access-date = 4 November 2015|url-status = live|archive-url = https://web.archive.org/web/20151117024132/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a06ea7d8-a884-4b62-a87f-c36d824f2aa4|archive-date = 17 November 2015}}</ref>
* ''[[Escherichia coli]]''
* ''[[Proteus mirabilis]]''
* ''[[Klebsiella pneumoniae]]''
* ''[[Enterobacter]]'' species
* [[Coagulase|Coagulase-negative]] ''[[Staphylococcus]]'' species, including [[Staphylococcus saprophyticus|''S. saprophyticus'']]
* ''[[Streptococcus pneumoniae]]''
* ''[[Haemophilus influenzae]]''