Editing Sly syndrome (section)

==Signs and symptoms==
The most severe cases of Sly syndrome can result in [[hydrops fetalis]], which results in [[fetus|fetal]] death or death soon after birth. Some people with Sly syndrome may begin to have symptoms in early childhood. Symptoms can include [[macrocephaly|an enlarged head]], [[hydrocephalus|fluid buildup in the brain]], coarse facial features, [[macroglossia|enlarged tongue]], [[hepatomegaly|enlarged liver]], [[splenomegaly|enlarged spleen]], problems with the [[heart valve]]s, and abdominal [[hernia]]s. People with Sly syndrome may also have [[sleep apnea]], frequent lung infections, and problems with vision secondary to cloudy [[cornea]]s. Sly syndrome causes various musculoskeletal abnormalities that worsen with age. These can include short stature, joint deformities, [[dysostosis multiplex]], [[spinal stenosis]], and [[carpal tunnel syndrome]].<ref name=GeneticsHomeReference/>

While some individuals have developmental delay, others may have normal intelligence.<ref name=GeneticsHomeReference/> However, the accumulation of GAGs in the brain usually leads to the slowing of development from ages 1–3, and then a loss of previously learned skills until death.<ref name=MPS_Society/>