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==Early life and career== Simon was born in Louisville, Kentucky, to Moritz (Morris) Flexner, a Jewish immigrant from [[Všeruby (Domažlice District)|Neumark]], [[Bohemia]], via several years in [[Strasbourg]], [[France]]; and Ester from [[Roden, Bavaria|Roden]], [[Germany]].<ref name="Autobiography">''Abraham Flexner: An Autobiography'', New York: SImon and Schuster, 1960, pp. 2–4.</ref> He was the fourth son of seven in a large family of nine children: Jacob, Henry, and Isadore; then Simon, followed by [[Bernard Flexner]], [[Abraham Flexner]], and Washington. The two sisters Mary and Gertrude were the youngest. Jacob became a pharmacist and physician, Bernard became a [[Zionist]] leader, and Abraham became an educator, eventually influencing the direction of medical education in the United States.<ref name="griffen">{{cite journal| pmc=1356289 | pmid=15166960 | volume=239 | issue=6 | title=Jacob: the other Flexner | journal=Ann Surg | pages=808–817 | last1 = Griffen Jr | first1 = WO | year=2004 | doi=10.1097/01.sla.0000128684.67062.39}}</ref> Simon first gained a degree from the [[Louisville College of Pharmacy]] and worked with his brother Jacob for eight years.<ref name="griffen"/>
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