Editing Proteome (section)

==Types of proteomes==
While proteome generally refers to the proteome of an organism, multicellular organisms may have very different proteomes in different cells, hence it is important to distinguish proteomes in cells and organisms.

A '''cellular proteome''' is the collection of proteins found in a particular [[cell (biology)|cell]] type under a particular set of environmental conditions such as exposure to [[hormone|hormone stimulation]].

It can also be useful to consider an organism's '''complete proteome''', which can be conceptualized as the complete set of proteins from all of the various cellular proteomes. This is very roughly the protein equivalent of the [[genome]].

The term ''proteome'' has also been used to refer to the collection of proteins in certain '''sub-cellular systems''', such as organelles. For instance, the [[Mitochondrion|mitochondrial]] proteome may consist of more than 3000 distinct proteins.<ref>{{cite journal |last1=Johnson |first1=D. T. |last2=Harris |first2=R. A. |last3=French |first3=S. |last4=Blair |first4=P. V. |last5=You |first5=J. |last6=Bemis |first6=K. G. |last7=Wang |first7=M. |last8=Balaban |first8=R. S. |date=2006 |title=Tissue heterogeneity of the mammalian mitochondrial proteome |url=https://doi.org/10.1152/ajpcell.00108.2006 |journal=American Journal of Physiology. Cell Physiology |volume=292 |issue=2 |pages=c689–c697 | pmid=16928776 | doi=10.1152/ajpcell.00108.2006|s2cid=24412700 }}</ref><ref>{{Cite journal|last1=Morgenstern|first1=Marcel|last2=Stiller|first2=Sebastian B.|last3=Lübbert|first3=Philipp|last4=Peikert|first4=Christian D.|last5=Dannenmaier|first5=Stefan|last6=Drepper|first6=Friedel|last7=Weill|first7=Uri|last8=Höß|first8=Philipp|last9=Feuerstein|first9=Reinhild|last10=Gebert|first10=Michael|last11=Bohnert|first11=Maria|date=June 2017|title=Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale|url= |journal=Cell Reports|volume=19|issue=13|pages=2836–2852|doi=10.1016/j.celrep.2017.06.014|issn=2211-1247|pmc=5494306|pmid=28658629}}</ref><ref>{{Cite journal|last=Gómez-Serrano|first=M|date=November 2018|title=Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease.|journal=Oxid Med Cell Longev|volume=2018|pages=1435934|pmid=30533169|pmc=6250043|doi=10.1155/2018/1435934|doi-access=free}}</ref>

The proteins in a '''virus''' can be called a ''[[Viral evolution#Origins|viral proteome]]''. Usually viral proteomes are predicted from the viral genome<ref>{{Cite journal|last=Uetz|first=P.|date=2004-10-15|title=From ORFeomes to Protein Interaction Maps in Viruses|journal=Genome Research|language=en|volume=14|issue=10b|pages=2029–2033|doi=10.1101/gr.2583304|pmid=15489322|issn=1088-9051|doi-access=free}}</ref> but some attempts have been made to determine all the proteins expressed from a virus genome, i.e. the viral proteome.<ref>{{Cite journal|last1=Maxwell|first1=Karen L.|last2=Frappier|first2=Lori|date=June 2007|title=Viral proteomics|journal=Microbiology and Molecular Biology Reviews |volume=71|issue=2|pages=398–411|doi=10.1128/MMBR.00042-06|issn=1092-2172|pmc=1899879|pmid=17554050}}</ref> More often, however, virus proteomics analyzes the changes of host proteins upon virus infection, so that in effect ''two'' proteomes (of virus and its host) are studied.<ref>{{Cite journal|last1=Viswanathan|first1=Kasinath|last2=Früh|first2=Klaus|date=December 2007|title=Viral proteomics: global evaluation of viruses and their interaction with the host|url=https://pubmed.ncbi.nlm.nih.gov/18067418|journal=Expert Review of Proteomics|volume=4|issue=6|pages=815–829|doi=10.1586/14789450.4.6.815|issn=1744-8387|pmid=18067418|s2cid=25742649}}</ref>