Editing Phosphodiesterase inhibitor (section)

==History==
The different forms or subtypes of phosphodiesterase were initially isolated from rat brains in the early 1970s<ref>{{cite journal | pmid = 4321663 | volume=10 | title=Multiple cyclic nucleotide phosphodiesterase activities from rat brain | year=1971 | journal=Biochemistry | pages=311–6 | vauthors=Thompson WJ, Appleman MM| issue=2 | doi=10.1021/bi00778a018 }}</ref><ref>{{cite journal |author1=Uzunov P. |author2=Weiss B. | year = 1972 | title = Separation of multiple molecular forms of cyclic adenosine 3',5'-monophosphate phosphodiesterase in rat cerebellum by polyacrylamide gel electrophoresis | journal = Biochim. Biophys. Acta | volume = 284 | issue = 1| pages = 220–226 | doi = 10.1016/0005-2744(72)90060-5 | pmid=4342220}}</ref> and were soon afterward shown to be selectively inhibited in the brain and in other tissues by a variety of drugs.<ref>{{cite journal | author = Weiss B | year = 1975 | title = Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase | journal = Adv. Cycl. Nucl. Res. | volume = 5 | pages = 195–211 | pmid = 165666 }}</ref><ref>{{cite journal | vauthors = Fertel R, Weiss B | year = 1976 | title = Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung | journal = Mol. Pharmacol. | volume = 12 | issue = 4| pages = 678–687 | pmid = 183099 }}</ref> The potential for selective phosphodiesterase inhibitors as therapeutic agents was predicted as early as 1977 by [[Benjamin Weiss (scientist)|Weiss]] and Hait.<ref>{{cite journal |author1=Weiss B. |author2=Hait W.N. | year = 1977 | title = Selective cyclic nucleotide phosphodiesterase inhibitors as potential therapeutic agents | journal = Annu. Rev. Pharmacol. Toxicol. | volume = 17 | pages = 441–477 | doi=10.1146/annurev.pa.17.040177.002301 | pmid=17360}}</ref> This prediction meanwhile has proved to be true in a variety of fields.