Editing Peroxisome (section)

==History==
Peroxisomes (microbodies) were first described by a Swedish doctoral student, J. Rhodin in 1954.<ref name="Rhodin_1954">{{cite journal|vauthors=Rhodin, J|year=1954|title=Correlation of ultrastructural organization and function in normal and experimentally changed proximal tubule cells of the mouse kidney|journal=Doctorate Thesis. Karolinska Institutet, Stockholm}}</ref> They were identified as organelles by [[Christian de Duve]] and Pierre Baudhuin in 1966.<ref name="deDuve1966">{{cite journal
 |last1 = de Duve
 |first1 = Christian
 |last2 = Baudhuin
 |first2 = Pierre
 | title = Peroxisomes (microbodies and related particles)
 | journal = Physiological Reviews
 | volume = 46
 | number = 2
 | pages = 323–357
 | doi = 10.1152/physrev.1966.46.2.323
 | year = 1966
|pmid = 5325972
 }}</ref> De Duve and co-workers discovered that peroxisomes contain several oxidases involved in the production of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) as well as [[catalase]] involved in the decomposition of H<sub>2</sub>O<sub>2</sub> to oxygen and water.<ref name="pmid4389648">{{cite journal | vauthors = de Duve C | title = The peroxisome: a new cytoplasmic organelle | journal = Proceedings of the Royal Society of London. Series B, Biological Sciences | volume = 173 | issue = 1030 | pages = 71–83 | date = April 1969 | pmid = 4389648 | doi = 10.1098/rspb.1969.0039 | bibcode = 1969RSPSB.173...71D | s2cid = 86579094 }}</ref> Due to their role in peroxide metabolism, De Duve named them “peroxisomes”, replacing the formerly used morphological term “microbodies”. Later, it was described that firefly luciferase is targeted to peroxisomes in mammalian cells, allowing the discovery of the import targeting signal for peroxisomes, and triggering many advances in the peroxisome biogenesis field.<ref>{{Cite journal|last1=Keller|first1=G. A.|last2=Gould|first2=S.|last3=Deluca|first3=M.|last4=Subramani|first4=S.|date=May 1987|title=Firefly luciferase is targeted to peroxisomes in mammalian cells.|journal=Proceedings of the National Academy of Sciences|volume=84|issue=10|pages=3264–3268|doi=10.1073/pnas.84.10.3264|pmid=3554235|pmc=304849|bibcode=1987PNAS...84.3264K|issn=0027-8424|doi-access=free}}</ref><ref>{{Cite journal|last=Gould|first=S. J.|date=Sep 1988|title=Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteins|journal=The Journal of Cell Biology|volume=107|issue=3|pages=897–905|doi=10.1083/jcb.107.3.897|pmid=2901422|pmc=2115268|issn=0021-9525}}</ref>