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==Applications== The rate and outcome of chemical reactions taking place in water often depends on the acidity of the water, and it is therefore useful to know the acidity of the water, typically measured by means of a pH meter.<ref name="Brittanica1">{{cite web|last1=Bell|first1=Ronald Percy|title=Acid-Base Reaction|url=https://www.britannica.com/science/acid-base-reaction|website=Encyclopaedia Britannica|publisher=Encyclopaedia Britannica, Inc.|access-date=21 March 2017}}</ref> Knowledge of pH is useful or critical in many situations, including [[chemical laboratory]] analyses. pH meters are used for [[soil]] measurements in [[agriculture]], [[water quality]] for [[municipal water]] supplies, [[swimming pools]], [[environmental remediation]]; [[brewing]] of wine or beer; [[manufacturing]], healthcare and clinical applications such as [[blood chemistry]]; and many other applications.<ref name="Global" /> Advances in the instrumentation and in [[detection]] have expanded the number of applications in which pH measurements can be conducted. The devices have been [[miniaturized]], enabling direct measurement of pH inside of [[living cells]].<ref name="MMB2010">{{cite book|last1=Loiselle|first1=F.B.|last2=Casey|first2=J.R.|title=Membrane Transporters in Drug Discovery and Development |chapter=Measurement of Intracellular pH |date=2010|volume=637|pages=311β31|doi=10.1007/978-1-60761-700-6_17|pmid=20419443|series=Methods in Molecular Biology|isbn=978-1-60761-699-3}}</ref> In addition to measuring the pH of liquids, specially designed electrodes are available to measure the pH of semi-solid substances, such as foods. These have tips suitable for piercing semi-solids, have electrode materials compatible with ingredients in food, and are resistant to clogging.<ref name="Handbook">{{cite web|title=pH Measurement Handbook|url=http://www.pragolab.cz/files/aktuality/2015-03/pH-Measurement-Handbook.pdf|website=PragoLab|publisher=Thermo Scientific, Inc.|access-date=22 March 2017}}</ref>
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