Editing Neurofibromatosis (section)

== Signs and symptoms ==
[[File:Lisch nodules.JPG|thumb|upright=1.3|[[Lisch nodule]]s as seen in NF1]]
[[File:Early neurofibromatosis.jpg|thumb|upright=1.3|Person with multiple small neurofibromas in the skin and a "café au lait spot" (bottom of photo, to the right of centre). A biopsy has been taken of one of the lesions.]]
Neurofibromatosis type 1 in early life may cause learning and [[behavior]] problems – about 60% of children who have NF1 have mild difficulty in school.<ref>{{Cite web |title=Neurofibromatosis |url=http://www.nhs.uk/conditions/Neurofibromatosis/pages/symptoms.aspx |url-status=live |archive-url=https://web.archive.org/web/20150925015544/http://www.nhs.uk/Conditions/Neurofibromatosis/Pages/Symptoms.aspx |archive-date=25 September 2015 |access-date=9 October 2015 |website=NHS Choices |publisher=NHS}}</ref> Signs the individual might have are as follows:<ref>{{Cite web |title=Neurofibromatosis |url=http://www.ninds.nih.gov/disorders/neurofibromatosis/detail_neurofibromatosis.htm |url-status=dead |archive-url=https://web.archive.org/web/20151004194320/http://www.ninds.nih.gov/disorders/neurofibromatosis/detail_neurofibromatosis.htm |archive-date=4 October 2015 |access-date=9 October 2015 |website=NINDS |publisher=NIH}}</ref><ref name="NINDS2">{{Cite web |date=23 February 2015 |title=NINDS Neurofibromatosis Information Page |url=http://www.ninds.nih.gov/disorders/neurofibromatosis/neurofibromatosis.htm |url-status=dead |archive-url=https://web.archive.org/web/20150404180516/http://www.ninds.nih.gov/disorders/neurofibromatosis/neurofibromatosis.htm |archive-date=4 April 2015 |access-date=2015-04-21}}</ref>
* Six or more light brown dermatological spots ("[[café au lait spot]]s")
* At least two [[neurofibroma]]s
* At least two growths on the eye's iris
* Abnormal growth of the spine ([[scoliosis]])
* [[Lisch nodule|Lisch nodules]]
* Tumors on the adrenal glands called [[Pheochromocytoma|pheochromocytomas]]

People with neurofibromatosis type 2 can exhibit the same type of skin symptoms as type 1, but not necessarily in every case.<ref name=":5">{{Cite journal |vauthors=Guha M |date=March 2011 |title=The Gale Encyclopedia of Genetic Disorders |journal=Reference Reviews |edition=3rd |location=Detroit, MI |publisher=Gale |volume=25 |issue=3 |pages=40–42 |doi=10.1108/09504121111119022 |isbn=978-1-4144-7602-5 |veditors=Fundukian LJ}}</ref> Symptoms may include pain due to pressure on nerves, [[tinnitus]], weakness in fingers, numbness, headaches. The symptom most characteristic of NF2 is hearing loss.<ref>{{Cite journal |last1=Selvanathan |first1=SK |last2=Shenton |first2=A |last3=Ferner |first3=R |last4=Wallace |first4=AJ |last5=Huson |first5=SM |last6=Ramsden |first6=RT |last7=Evans |first7=DG |date=2010-01-11 |title=Further genotype – phenotype correlations in neurofibromatosis 2 |url=http://dx.doi.org/10.1111/j.1399-0004.2009.01315.x |journal=Clinical Genetics |volume=77 |issue=2 |pages=163–170 |doi=10.1111/j.1399-0004.2009.01315.x |pmid=19968670 |s2cid=11130733 |issn=0009-9163}}</ref> The hearing loss occurs due to the pressure of tumors on the acoustic nerve. The same pressure can cause headaches, dizziness, and nausea.<ref name=":5" />

The main symptom of schwannomatosis is localized pain. This pain is due to tissues and nerves experiencing more pressure because of nearby tumors.<ref name=":42" />

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File:Neurofibromatosis type II tumor types.png|Figure of various morbidities associated with neurofibromatosis type II.<ref name="pmid33445724">{{cite journal |author1=Bachir S |author2=Shah S |author3=Shapiro S |author4=Koehler A |author5=Mahammedi A |author6=Samy RN | display-authors=etal| title=Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis. | journal=Int J Mol Sci | year= 2021 | volume= 22 | issue= 2 | page=690| pmid=33445724 | doi=10.3390/ijms22020690 | pmc=7828193 | doi-access=free}}</ref>
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