Editing Ibuprofen (section)

==Medical uses==
[[File:200mg ibuprofen tablets.jpg|thumb|Example of some 200 mg ibuprofen tablets]]
[[File:Ibuprofen syrup.jpg|thumb|A 150 ml bottle (100 mg/5 ml dosage) of ibuprofen, sold in Greece]]
Ibuprofen is used primarily to treat [[fever]] (including post-vaccination fever), mild to moderate [[pain]] (including pain relief after [[surgery]]), [[dysmenorrhoea|painful menstruation]], [[osteoarthritis]], dental pain, [[headache]]s, and [[renal colic|pain from kidney stones]]. About 60% of people respond to any NSAID; those who do not respond well to a particular one may respond to another.<ref>{{cite web |url=https://www.evidence.nhs.uk/formulary/bnf/current/10-musculoskeletal-and-joint-diseases/101-drugs-used-in-rheumatic-diseases-and-gout/1011-non-steroidal-anti-inflammatory-drugs |title=10.1.1 Non-steroidal anti-inflammatory drugs |website=British National Formulary |author=<!-- not stated --> |access-date=13 April 2016 |url-status=dead |archive-url=https://web.archive.org/web/20161117090028/http://www.evidence.nhs.uk/formulary/bnf/current/10-musculoskeletal-and-joint-diseases/101-drugs-used-in-rheumatic-diseases-and-gout/1011-non-steroidal-anti-inflammatory-drugs |archive-date=17 November 2016 }}</ref> A Cochrane medical review of 51 trials of NSAIDs for the treatment of [[lower back pain]] found that "NSAIDs are effective for short-term symptomatic relief in patients with acute low back pain".<ref>{{cite journal | vauthors = Griffin G, Tudiver F, Grant WD | title = Do NSAIDs help in acute or chronic low back pain? | journal = American Family Physician | volume = 65 | issue = 7 | pages = 1319–1321 | date = April 2002 | pmid = 11996413 | url = https://www.aafp.org/pubs/afp/issues/2002/0401/p1319.html | access-date = 19 January 2023 | archive-date = 19 January 2023 | archive-url = https://web.archive.org/web/20230119180318/https://www.aafp.org/pubs/afp/issues/2002/0401/p1319.html | url-status = live }}</ref>

It is used for inflammatory diseases such as [[juvenile idiopathic arthritis]] and [[rheumatoid arthritis]].<ref name="BNF">{{cite book | isbn = 978-0-85711-084-8 | title = British National Formulary (BNF) | last1 = Joint Formulary Committee | year = 2013 | publisher = Pharmaceutical Press | location = London, UK | edition = 65 | pages = [https://archive.org/details/bnf65britishnati0000unse/page/665 665], 671 | url = https://archive.org/details/bnf65britishnati0000unse/page/665 }}</ref><ref name="AMH">{{cite book | veditors = Rossi S | isbn = 978-0-9805790-9-3 | title = Australian Medicines Handbook | place = Adelaide | publisher = The Australian Medicines Handbook Unit Trust | year = 2013 | edition = 2013 }}</ref> It is also used for [[pericarditis]] and to close a [[patent ductus arteriosus]] in a [[premature baby]].<ref name="Pedea EPAR">{{cite web | title=Pedea EPAR | website=[[European Medicines Agency]] (EMA) | date=29 July 2004 | url=https://www.ema.europa.eu/en/medicines/human/EPAR/pedea | access-date=24 February 2024}}</ref><ref name="AHFS2016" /><ref name="Alabed2014">{{cite journal | vauthors = Alabed S, Cabello JB, Irving GJ, Qintar M, Burls A | title = Colchicine for pericarditis | journal = The Cochrane Database of Systematic Reviews | volume = 2014 | issue = 8 | pages = CD010652 | date = August 2014 | pmid = 25164988 | doi = 10.1002/14651858.CD010652.pub2 | pmc = 10645160 | url = http://openaccess.city.ac.uk/4043/5/Colchicine%20for%20pericarditis.pdf | type = Review | access-date = 26 January 2019 | archive-date = 22 September 2017 | archive-url = https://web.archive.org/web/20170922013941/http://openaccess.city.ac.uk/4043/5/Colchicine%20for%20pericarditis.pdf | url-status = live }}</ref><ref name="Rostas2016">{{cite journal | vauthors = Rostas SE, McPherson CC | title = Pharmacotherapy for Patent Ductus Arteriosus: Current Options and Outstanding Questions | journal = Current Pediatric Reviews | volume = 12 | issue = 2 | pages = 110–119 | date = 2016 | pmid = 27197952 | doi = 10.2174/157339631202160506002028 | type = Review }}</ref>

===Ibuprofen lysine===

In some countries, ibuprofen [[lysine]] (the lysine salt of ibuprofen, sometimes called "ibuprofen lysinate") is licensed for treatment of the same conditions as ibuprofen; the lysine salt is used because it is more water-soluble.<ref>{{cite journal | vauthors = Beaver WT | title = Review of the analgesic efficacy of ibuprofen | journal = International Journal of Clinical Practice. Supplement | issue = 135 | pages = 13–17 | date = April 2003 | pmid = 12723741 }}</ref> However, subsequent studies shown no statistical differences between the lysine salt and ibuprofen base.<ref>{{cite journal | vauthors = Kyselovič J, Koscova E, Lampert A, Weiser T | title = A Randomized, Double-Blind, Placebo-Controlled Trial of Ibuprofen Lysinate in Comparison to Ibuprofen Acid for Acute Postoperative Dental Pain | journal = Pain and Therapy | volume = 9 | issue = 1 | pages = 249–259 | date = June 2020 | pmid = 31912434 | pmc = 7203382 | doi = 10.1007/s40122-019-00148-1 }}</ref><ref>{{cite journal | vauthors = Moore AR, Derry S, Straube S, Ireson-Paine J, Wiffen PJ | title = Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain | journal = Pain | volume = 155 | issue = 1 | pages = 14–21 | date = January 2014 | pmid = 23969325 | doi = 10.1016/j.pain.2013.08.013 }}</ref>

In 2006, ibuprofen lysine was approved in the United States by the [[Food and Drug Administration]] (FDA) for closure of patent ductus arteriosus in premature infants weighing between {{cvt|500|and|1500|g|lb|0|abbr=on}}, who are no more than 32 weeks gestational age when usual medical management (such as fluid restriction, diuretics, and respiratory support) is not effective.<ref>{{cite journal | vauthors = Fanos V, Antonucci R, Zaffanello M | title = Ibuprofen and acute kidney injury in the newborn | journal = The Turkish Journal of Pediatrics | volume = 52 | issue = 3 | pages = 231–238 | year = 2010 | pmid = 20718179 }}</ref>