Editing Hydrophobe (section)

==Chemical background==
{{Main|Hydrophobic effect}}

The hydrophobic interaction is mostly an [[entropy|entropic]] effect originating from the disruption of the highly dynamic [[hydrogen bond]]s between molecules of liquid water by the nonpolar solute, causing the water to compensate by forming a [[clathrate]]-like cage structure around the non-polar molecules. This structure is more highly ordered than free water molecules due to the water molecules arranging themselves to interact as much as possible with themselves, and thus results in a lower entropic state at the interface. This causes non-polar molecules to clump together to reduce the [[accessible surface area|surface area exposed to water]] and thereby increase the entropy of the system.<ref>{{cite book |last1=Garrett |first1=Reginald |last2=Grisham |first2=Charles|title=Biochemistry |date=January 5, 2012|publisher=Cengage Learning |pages=31–35 |isbn=978-1133106296}}</ref><ref>{{cite journal |vauthors= Silverstein TP |title= The Real Reason Why Oil and Water Don't Mix |journal= Journal of Chemical Education |volume= 75 |issue= 1 |pages= 116–346 |year= 1998 |doi= 10.1021/ed075p116 |url= https://www.docdroid.net/file/download/EnMrRWi/the-real-reason-why-oil-and-water-dont-mix.pdf |via=DocDroid |access-date= 9 December 2011 |bibcode= 1998JChEd..75..116S}}</ref> Thus, the two immiscible phases (hydrophilic vs. hydrophobic) will change so that their corresponding interfacial area will be minimal. This effect can be visualized in the phenomenon called [[phase (matter)|phase]] separation.{{Citation needed|date=January 2021}}