Editing Hand, foot, and mouth disease (section)

== Signs and symptoms ==

Common constitutional signs and symptoms of HFMD include fever, nausea, vomiting, [[fatigue|feeling tired]], [[malaise|generalized discomfort]], [[Anorexia (symptom)|loss of appetite]], and irritability in infants and toddlers. Skin lesions frequently develop in the form of a [[maculopapular|rash of flat discolored spots and bumps]] which may be followed by [[vesicle (dermatology)|vesicular sores]] with [[blister]]s on palms of the hands, soles of the feet, buttocks, and sometimes on the lips.<ref name="Huang1999">{{cite journal|last1=Huang|first1=CC|last2=Liu|first2=CC|last3=Chang|first3=YC|last4=Chen|first4=CY|last5=Wang|first5=ST|last6=Yeh|first6=TF|title=Neurologic complications in children with enterovirus 71 infection.|journal=The New England Journal of Medicine|date=September 23, 1999|volume=341|issue=13|pages=936–42|pmid=10498488|doi=10.1056/nejm199909233411302|doi-access=free}}</ref> The rash is rarely itchy for children,<ref name=Hoy2012/> but can be extremely itchy for adults. [[Pain]]ful facial [[ulcer]]s, [[blister]]s, or lesions may also develop in or around the nose or [[Human mouth|mouth]].<ref name=Kam2013/><ref name=Sar2013/><ref name='HFMD Symptoms'>{{Cite web |url=http://www.mayoclinic.com/health/hand-foot-and-mouth-disease/DS00599/DSECTION=2 |title=Hand, Foot and Mouth Disease: Signs & Symptoms |access-date=May 5, 2008 |work=mayoclinic.com |publisher=The Mayo Clinic |url-status=live |archive-url=https://web.archive.org/web/20080501111320/http://www.mayoclinic.com/health/hand-foot-and-mouth-disease/DS00599/DSECTION%3D2 |archive-date=May 1, 2008  }}</ref> HFMD usually resolves on its own after 7–10 days.<ref name=Sar2013/> Most cases of the disease are relatively harmless, but complications including encephalitis, meningitis, and paralysis that mimics the neurological symptoms of polio can occur.<ref>{{Cite web|url=http://www.wpro.who.int/topics/hand_foot_mouth/en/|archive-url=https://web.archive.org/web/20120423165020/http://www.wpro.who.int/topics/hand_foot_mouth/en/|url-status=dead|archive-date=April 23, 2012|title=Hand, Foot and Mouth Disease (HFMD)|website=WHO Western Pacific Region|language=en-GB|access-date=November 6, 2017}}</ref>

<gallery widths="220" heights="220">
Image:Characteristic rash of hand, foot, and mouth disease, on human hands.jpg|Rash on palms of the hands
File:Hand Foot Mouth Disease Adult 36Years.jpg|Rash on hands and feet of a 36-year-old man
File:Hand foot and mouth disease on child feet.jpg|Rash on the soles of a child's feet
</gallery>