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Graves' disease
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==Signs and symptoms== {{Main|Signs and symptoms of Graves' disease}} [[Image:HyperaldosteronismSymptoms.jpeg|thumb|upright=1.3|Graves disease symptoms]] The signs and symptoms of Graves disease virtually all result from the direct and indirect effects of hyperthyroidism, with main exceptions being [[Graves ophthalmopathy]], [[goiter]], and [[pretibial myxedema]] (which are caused by the autoimmune processes of the disease). Symptoms of the resultant hyperthyroidism are mainly [[insomnia]], hand [[tremor]], [[hyperactivity]], hair loss, excessive [[sweating]], [[oligomenorrhea]], itching, [[heat intolerance]], [[weight loss]] despite [[increased appetite]], [[diarrhea]], frequent [[defecation]], [[palpitation]]s, [[muscle weakness|periodic partial muscle weakness or paralysis]] in those especially of Asian descent,<ref>{{cite book|last1=N. Burrow|first1=Gerard|last2=H. Oppenheimer|first2=Jack|last3=VolpΓ©|first3=Robert|name-list-style=vanc|title=Thyroid function & disease|date=1989|publisher=W.B. Saunders |isbn=0721621902|url-access=registration|url=https://archive.org/details/thyroidfunctiond00burr}}</ref> and skin warmth and moistness.<ref name=agabegi2nd157>page 157 in:{{cite book | first1 = Elizabeth D | last1 = Agabegi | last2 = Agabegi | first2 = Steven S. | name-list-style = vanc | title = Step-Up to Medicine (Step-Up Series) | publisher = Lippincott Williams & Wilkins | location = Hagerstwon, MD | year = 2008 | isbn = 978-0-7817-7153-5 | url-access = registration | url = https://archive.org/details/stepuptomedicine0000agab }}</ref> Further signs that may be seen on [[physical examination]] are most commonly a diffusely enlarged (usually symmetric), nontender thyroid, [[lid lag]], excessive [[tears|lacrimation]] due to Graves' ophthalmopathy, [[Heart arrhythmia|arrhythmia]]s of the heart, such as [[sinus tachycardia]], [[atrial fibrillation]], and [[premature ventricular contraction]]s, and [[hypertension]].<ref name=agabegi2nd157/><ref>{{cite journal | vauthors = Bunevicius R, Prange AJ | title = Psychiatric manifestations of Graves hyperthyroidism: pathophysiology and treatment options | journal = CNS Drugs | volume = 20 | issue = 11 | pages = 897β909 | year = 2006 | pmid = 17044727 | doi = 10.2165/00023210-200620110-00003 | s2cid = 20003511 }}</ref>
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