Editing Gene knockout (section)

==Methods==
Knockouts are accomplished through a variety of techniques. Originally, '''naturally occurring [[mutation]]s''' were identified and then gene loss or inactivation had to be established by [[DNA sequencing]] or other methods.<ref>{{cite book | url=https://www.ncbi.nlm.nih.gov/books/NBK21766/?term=knockout | title = An Introduction to Genetic Analysis | edition = 7th | vauthors = Griffiths AJ, Miller JH, Suzuki DT, Lewontin WC, Gelbart WM | isbn = 978-0-7167-3771-1 | location = New York | publisher = W. H. Freeman | year = 2000 }}</ref>[[File:Knockout Mice5006-300.jpg|thumb|A laboratory mouse in which a gene affecting hair growth has been knocked out (left), is shown next to a normal lab mouse.]]