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==Signs and symptoms== Symptoms of this disease typically begin within 2 weeks of contact with the causative organism. Signs/Symptoms may include:<ref name=":5" /> * Fever * Chills * Headache * Confusion * Cough * Rapid Breathing * Body/Muscle Aches * Rash * Nausea * Vomiting After 5–6 days, a macular skin eruption develops: first on the upper trunk and spreading to the rest of the body (rarely to the face, palms, or soles of the feet, however).<ref name=":5" /> [[Brill–Zinsser disease]], first described by [[Nathan Brill]] in 1913 at [[Mount Sinai Hospital, New York|Mount Sinai Hospital]] in [[New York City]], is a mild form of epidemic typhus that recurs in someone after a long period of latency (similar to the relationship between [[chickenpox]] and [[shingles]]). This recurrence often arises in times of relative [[immunosuppression]], which is often in the context of a person suffering malnutrition or other illnesses. In combination with poor sanitation and hygiene in times of social chaos and upheaval, which enable a greater density of [[lice]], this reactivation is why typhus generates epidemics in such conditions.<ref>{{cite journal |last1=Raoult |first1=D. |last2=Roux |first2=V. |last3=Ndihokubwayo |first3=J.B. |last4=Bise |first4=G. |last5=Baudon |first5=D. |last6=Martet |first6=G. |last7=Birtles |first7=R. |title=Jail Fever (Epidemic Typhus) Outbreak in Burundi |journal=Emerging Infectious Diseases |date=September 1997 |volume=3 |issue=3 |pages=357–360 |doi=10.3201/eid0303.970313 |pmid=9284381 |url=https://wwwnc.cdc.gov/eid/article/3/3/97-0313_article |access-date=15 January 2025}}</ref> === Complications === Complications are as follows{{citation needed|date=May 2021}} * [[Myocarditis]] * [[Endocarditis]] * [[Mycotic aneurysm]] * [[Pneumonia]] * [[Pancreatitis]] * Kidney or bladder infections * Acute renal failure * [[Meningitis]] * Encephalitis * Myelitis * Septic shock
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