Editing Cytoskeleton (section)

==History==
In 1903, [[Nikolai Koltsov|Nikolai K. Koltsov]] proposed that the shape of cells was determined by a network of tubules that he termed the cytoskeleton. The concept of a protein mosaic that dynamically coordinated cytoplasmic biochemistry was proposed by Rudolph Peters in 1929<ref>{{cite journal |author=Peters RA |title= The Harben Lectures, 1929. Reprinted in: Peters, R. A. (1963) Biochemical lesions and lethal synthesis, p. 216. Pergamon Press, Oxford. }}</ref> while the term (''cytosquelette'', in French) was first introduced by French embryologist [[Paul Wintrebert]] in 1931.<ref>{{cite journal | vauthors = Frixione E | s2cid = 16728876 | title = Recurring views on the structure and function of the cytoskeleton: a 300-year epic | journal = Cell Motility and the Cytoskeleton | volume = 46 | issue = 2 | pages = 73–94 | date = June 2000 | pmid = 10891854 | doi = 10.1002/1097-0169(200006)46:2<73::AID-CM1>3.0.CO;2-0 }}</ref>

When the cytoskeleton was first introduced, it was thought to be an uninteresting gel-like substance that helped organelles stay in place.<ref>{{cite book|last1=Hardin|first1=Jeff| name-list-style = vanc |title=Becker's World of the Cell|publisher=Pearson|isbn=978-0-321-93492-5|pages=351|edition=9th|date=2015-12-03}}</ref> Much research took place to try to understand the purpose of the cytoskeleton and its components.

Initially, it was thought that the cytoskeleton was exclusive to eukaryotes but in 1992 it was discovered to be present in prokaryotes as well. This discovery came after the realization that bacteria possess proteins that are homologous to tubulin and actin; the main components of the eukaryotic cytoskeleton.<ref>{{cite journal | vauthors = Wickstead B, Gull K | title = The evolution of the cytoskeleton | journal = The Journal of Cell Biology | volume = 194 | issue = 4 | pages = 513–25 | date = August 2011 | pmid = 21859859 | pmc = 3160578 | doi = 10.1083/jcb.201102065 }}</ref>