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==Causes== Acidic, sandy, or coarse [[soil]]s often contain less calcium. Uneven soil moisture and overuse of [[fertilizer]]s can also cause calcium deficiency. At times, even with sufficient calcium in the soil, it can be in an insoluble form and is then unusable by the plant or it could be attributed to a "transport protein".<ref name="transport protein identified">{{Cite web |last=Zurich |first=University of |title=Blossom end rot: Transport protein identified |url=https://phys.org/news/2011-11-blossom-protein.html |access-date=2025-03-03 |website=phys.org |language=en}}</ref> Soils containing high phosphorus are particularly susceptible to creating insoluble forms of calcium.{{Citation needed|date=July 2018}} Calcium and [[magnesium]] are opposed within the plant cells, and have antagonistic interactions. As a result, a homeostatic balance between Ca and Mg within the plant is necessary for optimal growth and proper development.<ref>{{Cite journal|date=2017-10-01|title=Regulation of calcium and magnesium homeostasis in plants: from transporters to signaling network|journal=Current Opinion in Plant Biology|language=en|volume=39|pages=97β105|doi=10.1016/j.pbi.2017.06.009|issn=1369-5266|last1=Tang|first1=Ren-Jie|last2=Luan|first2=Sheng|pmid=28709026|bibcode=2017COPB...39...97T }}</ref>
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