Editing Antiplatelet drug (section)

==Choice==
Antiplatelet medications are one of the primary recommendations for treatment of both stable<ref name=":3">{{cite journal | vauthors = Fihn SD, Gardin JM, Abrams J, Berra K, Blankenship JC, Dallas AP, Douglas PS, Foody JM, Gerber TC, Hinderliter AL, King SB, Kligfield PD, Krumholz HM, Kwong RY, Lim MJ, Linderbaum JA, Mack MJ, Munger MA, Prager RL, Sabik JF, Shaw LJ, Sikkema JD, Smith CR, Smith SC, Spertus JA, Williams SV, Anderson JL | display-authors = 6 | title = 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart diseasem | collaboration = American College of Cardiology Foundation/American Heart Association task force on practice guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons | journal = Circulation | volume = 126 | issue = 25 | pages = e354–e471 | date = December 2012 | pmid = 23166211 | doi = 10.1161/CIR.0b013e318277d6a0 | doi-access = free }}</ref> and unstable<ref name=":4">{{cite journal | vauthors = Wright RS, Anderson JL, Adams CD, Bridges CR, Casey DE, Ettinger SM, Fesmire FM, Ganiats TG, Jneid H, Lincoff AM, Peterson ED, Philippides GJ, Theroux P, Wenger NK, Zidar JP, Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE, Chavey WE, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS | display-authors = 6 | title = 2011 ACCF/AHA focused update of the Guidelines for the Management of Patients with Unstable Angina/Non-ST-Elevation Myocardial Infarction (updating the 2007 guideline) | collaboration = American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in collaboration with the American College of Emergency Physicians, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons | journal = Journal of the American College of Cardiology | volume = 57 | issue = 19 | pages = 1920–1959 | date = May 2011 | pmid = 21450428 | doi = 10.1016/j.jacc.2011.02.009 | doi-access = free }}</ref> [[Coronary artery disease|ischemic heart disease]]. Most commonly, [[aspirin]] is used as a single medication in cases of uncomplicated [[stable angina]], and in some cases of [[unstable angina]]. If a patient [[Salicylate sensitivity|does not tolerate aspirin]], ADP/P2Y inhibitors may be used as single-drug therapy instead. More severe and complicated cases are treated with dual antiplatelet therapy, or in some cases triple therapy that includes [[direct oral anticoagulants]].<ref>{{cite journal | vauthors = Gurbel PA, Fox KA, Tantry US, Ten Cate H, Weitz JI | title = Combination Antiplatelet and Oral Anticoagulant Therapy in Patients With Coronary and Peripheral Artery Disease | journal = Circulation | volume = 139 | issue = 18 | pages = 2170–2185 | date = April 2019 | pmid = 31034291 | doi = 10.1161/CIRCULATIONAHA.118.033580 | s2cid = 207592252 | doi-access = free }}</ref> Clinicians must make a choice that balances patient risk with the increased risks of bleeding associated with combination therapy.<ref name=":3" /><ref name=":4" />