Editing 7-Dehydrocholesterol (section)

==Biosynthesis==
It is synthesized from [[lathosterol]] by the enzyme [[lathosterol oxidase]] (lathosterol 5-desaturase).  This is the next-to-last step of cholesterol biosynthesis.<ref name="pmid12812989">{{cite journal | vauthors = Krakowiak PA, Wassif CA, Kratz L, Cozma D, Kovárová M, Harris G, Grinberg A, Yang Y, Hunter AG, Tsokos M, Kelley RI, Porter FD | title = Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency | journal = Human Molecular Genetics | volume = 12 | issue = 13 | pages = 1631–41 | date = July 2003 | pmid = 12812989 | doi = 10.1093/hmg/ddg172 | url = | doi-access = free }}</ref>  Defective synthesis results in the human inherited disorder [[lathosterolosis]] resembling [[Smith–Lemli–Opitz syndrome]].<ref name="pmid12812989"/>  Mice where this gene has been deleted lose the ability to increase vitamin D<sub>3</sub> in the blood following UV exposure of the skin.<ref name="pmid28330720">{{cite journal | vauthors = Makarova AM, Pasta S, Watson G, Shackleton C, Epstein EH | title = Attenuation of UVR-induced vitamin D3 synthesis in a mouse model deleted for keratinocyte lathosterol 5-desaturase | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 171| pages = 187–194 | date = July 2017 | pmid = 28330720 | doi = 10.1016/j.jsbmb.2017.03.017 | s2cid = 206502190 | url = https://research.birmingham.ac.uk/portal/en/publications/attenuation-of-uvrinduced-vitamin-d3-synthesis-in-a-mouse-model-deleted-for-keratinocyte-lathosterol-5desaturase(11f96b2b-f9ff-4ea7-b10d-25547481754c).html}}</ref>